N2 Biomedical’s proprietary NanoTitanium coatings improve the osseo-integrative and anti-microbial properties of polyetheretherketone (PEEK) implants
PEEK has increasingly been used as an implant material for orthopedic and spinal devices, in part due to its inherent properties such chemical inertness, radiolucency, and an elastic modulus that is closely matched to natural bone. Despite these advantages, a major limitation of untreated PEEK implants is their hydrophobic surface which leads to relatively poor bone tissue attachment as compared to titanium-based devices.
N2's proprietary nano-engineered Ti coatings on PEEK can promote and increase new bone growth and provide a preferred track for the formation and attachment of bone tissue on selected areas of PEEK implants. N2's nano-scale surface texturing process also improves antimicrobial properties while maintaining excellent osseo-integration.
NanoTitanium coatings are applied with Ion Beam Assisted Deposition (IBAD), which deposits a highly adherent thin film using a low-temperature, vacuum coating process. This process combines evaporation with concurrent ion beam bombardment in a high vacuum environment. Unlike conventional Physical Vapor Deposition (PVD) coatings, which rest only on the surface, the concurrent ion bombardment intermixes coating and substrate atoms and significantly improves adhesion while permitting control of morphology, density, stress level, crystallinity, and chemical composition. The ion bombardment also eliminates the columnar microstructure often observed in conventional, low temperature physical vapor deposition to create very dense, adherent film structures.

NanoTitanium Coatings
Titanium and titanium oxide coatings are deposited as highly adherent thin films at a low temperature using our ion beam assisted deposition (IBAD) process. These nanostructured coatings significantly improve the biocompatibility and functionality of orthopedic implants and are particularly useful for PEEK components. These nanostructured films have been engineered to encourage osteoblast differentiation and proliferation while preventing bacterial attachment and biofilm formation.
APPLICATIONS
- Spinal interbodies
- Dental implants
- PEEK screws
- Small joints
BENEFITS
- Improves biocompatibility of substrate material
- Increases surface area
- Creates beneficial surface textures
SUBSTRATES
- PEEK
- Stainless steel
- Cobalt-chromium
- Titanium
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A major limitation of untreated PEEK implants is their hydrophobic surface which leads to relatively poor bone tissue attachment as compared to titanium-based devices. N2's proprietary IBAD applied, nano-engineered Ti coatings on PEEK can promote and increase new bone growth and provide a preferred track for the formation and attachment of bone tissue as well as improve antimicrobial properties while maintaining excellent osseo-integration. This datasheet covers features, benefits and applications.

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Substrates Commonly Treated with Ion Implantation and Ion Beam Assisted Deposition
Improved surface
hardness
Reduced
Friction
Reduced
Corrosion
Improved
Wettability
Reduced
Biofilm
Improved
Antimicrobial
Improved
Biocompatibility
Improved
Aesthetics